Inclusion criteria
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1. Meet the novel coronavirus diagnostic criteria for asymptomatic infection
Tibetan Medicine Diagnosis and Treatment Plan for COVID-19 in Tibet Autonomous Region (trial version 3).
The COVID-19 nucleic acid test was positive. No clinical manifestations or imaging manifestations of pneumonia.
2. Meet the novel coronavirus diagnostic criteria for mild coronavirus;
Mild cases may present with fever, dry cough, headache, sore throat, etc. The clinical symptoms were mild, and imaging showed no signs of pneumonia.
2.1 General Inspection
In the early stage of the disease, the total number of peripheral blood white blood cells is normal or decreased, and the lymphocyte count is decreased. Some patients may have increased liver enzymes, lactate dehydrogenase, muscle enzymes, myoglobin, troponin and ferritin. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were elevated in most patients, while procalcitonin (PCT) was normal. In severe and critical patients, D-dimer increased, peripheral blood lymphocytes decreased progressively, and inflammatory factors increased.
2.2 Etiological and serological examination
2.2.1 Pathogenic examination: Test novel coronavirus nucleic acid on nose and oropharyngeal swabs, sputum and other lower respiratory tract secretions, and feces by nucleic acid amplification test. Nucleic acid detection will be affected by the course of disease, specimen collection, detection process, detection reagents and other factors. In order to improve the accuracy of detection, the collection of specimens should be standardized, and specimens should be submitted to test as soon as possible after collection.
2.2.2 Serological examination: novel coronavirus specific IgM and IgG antibodies are positive, and the positive rate within 1 week after onset is low.
2.3 Chest Imaging
In the early stage, multiple small patches and interstitial changes were observed, especially in the outer lung zone. Further, it develops into multiple ground-glass shadows and infiltrating shadows in both lungs. In severe cases, lung consolidation may occur, and pleural effusion is rare. At MIS-C, cardiac shadow enlargement and pulmonary edema can be seen in patients with cardiac dysfunction.
3. It meets the development stage standards of immature fever and mature fever of Tibetan medical diseases;
Tibetan Medicine Diagnosis and Treatment Plan for COVID-19 in Tibet Autonomous Region (trial version 4).
3.1 Symptoms of disease
Immature heat stage: manifested as headache, fatigue, limb pain, frequent yawn, body shivering, dream, chills, fever, deafness of both ears, like sun exposure, bitter mouth, do not think about food, malaise, especially the first night pain. The pulse is fine and sometimes shaken, and the urine is cloudy.
Ripe heat stage: fever, fatigue, sweating, red eyes, yellow and greasy tongue coating, headache, polydipsia, wandering consciousness, etc. Pulse fine tight and number, red and yellow urine color, strong taste gas.
Cold and hot junction period: lumbar acid bone pain, sweating less sleep, dizziness, tinnitus, red and dry tongue rough, frequent empty vomiting, delirium, occasional body trembling, body surface fever. Pulse virtual and number, urine red clear, foam.
3.2 Specific symptoms
When the disease invaded the lungs, it was manifested as chest, ribs and back pain, shortness of breath, cough, red and yellow phlegm, smell and other symptoms. The main manifestations were sore throat, pharyngeal discomfort, cough, cough of white foamy sputum and fatigue. Some patients can have nasal congestion, runny nose, sore throat, hypoxia or loss of smell and taste, conjunctivitis, myalgia and diarrhea as the main manifestations. Due to individual differences, some patients have no obvious clinical symptoms and need to be confirmed by auxiliary examination.
4. Patients aged 16-70 years;
5. Inform the content of informed consent and agree to participate in the clinical investigator.
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