Exclusion criteria:
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Western medicine exclusion criteria:
1.Constipation type, mixed type, atypical irritable bowel syndrome and other organic diseases of digestive system, or other organic diseases causing abdominal pain and discomfort;
2.It was confirmed by examination as infectious diarrhea, inflammatory bowel disease, parasitic infection, positive fecal occult blood, colorectal tumor, malabsorption syndrome, lactose intolerance (combined with history) and diarrhea caused by systemic diseases;
3.Patients with diabetes mellitus, hyperthyroidism, or severe primary diseases such as heart, brain, liver, kidney, hematopoietic system, or severe diseases affecting their survival (such as tumor), or abnormal liver and kidney functions (BUN, Cr) (alt, AST > 1.5 times of the upper limit of normal range, Cr > the upper limit of normal range), and patients with abnormal ECG of clinical significance;
4.Patients with history of nervous system disease and mental illness;
5.Previous gastrointestinal surgery (except caesarean section and appendectomy);
6.Patients are or need to continue to use drugs that may affect gastrointestinal motility (anticholinergic drugs, 5-HT3 receptor antagonists, antidiarrheal agents, antacids, prokinetic drugs, antidepressants, anxiolytics, intestinal flora regulators, etc.), or those who have used other traditional Chinese and Western drugs for the treatment of irritable bowel syndrome in the past 2 weeks;
7.Allergic constitution, with a history of drug allergy and severe food allergy;
8.Suspect or have a history of alcohol or drug abuse;
9.Pregnant and lactating women, and those with recent pregnancy planning;
10.Cognitive impairment, can not give full informed consent;
11.Patients who participated in other clinical trials in the past one month;
12.The researchers believe that there are patients who are not suitable for inclusion.
TCM inclusion criteria:
Exclusion criteria of combined syndrome of liver depression and spleen deficiency:
Damp-heat, heavy head, chest distress, greasy mouth, limb drowsiness or soreness; yellow and greasy tongue coating. Patients met the above two items could not be included in this study.
Spleen and stomach deficiency cold syndrome, stomach dull pain, fasting aggravated, relieved after eating, like to press, vomiting water; hands and feet are not warm, stool is not formed. Patients met the above two items could not be included in this study.
Stagnation of liver-qi, fever, aversion to fever; thirst like to drink cold water, sweating; dry stool or constipation, small urine volume color yellow, red complexion; purple red tongue, yellow or grayish black tongue coating and dry, increased pulse rate, strong pulsation. Patients met the above two items could not be included in this study.
Kidney yin deficiency, waist and knee pain; vertigo and tinnitus; male spermatorrhea; female menstrual disorders; fever due to yin deficiency. Patients met the above two items could not be included in this study.
Kidney deficiency, soreness and weakness of waist and knees, exhaustion; more times of urination, clear urine, or incomplete emptying, or enuresis, or more times of urination at night, or urinary incontinence; men slippery sperm, premature ejaculation, women with long duration of menstruation, or leucorrhea, or easy abortion of the fetus; pale tongue, white tongue coating, weak pulse. Patients met the above two items could not be included in this study.
Kidney yang deficiency, male impotence, premature ejaculation, cold semen, women are not easy to become pregnant, loss of libido; stool frequency is not formed, defecation in the early morning; urine frequency, urine color is light, increased nocturia; cold limbs, waist and knee cold pain. Patients met the above two items could not be included in this study.
Exclusion criteria for combined syndrome of spleen deficiency and dampness syndrome:
Damp-heat, chest distress, irritability, thirst; dry mouth, bitter taste; yellow and greasy tongue coating. Patients met the above two items could not be included in this study.
Spleen and stomach deficiency cold syndrome, stomach dull pain, fasting aggravated, relieved after eating, like to press, vomiting water; hands and feet are not warm, stool is not formed. Patients met the above two items could not be included in this study.
Blood stasis, dull complexion, dark tongue or ecchymosis; two flank tingling; women feel abdominal pain during menstruation, menstrual color dark red with blood clots. Patients met the above two items could not be included in this study.
Liver qi stagnation, chest discomfort, often sigh; often belching, depressed mood. Patients met the above two items could not be included in this study.
Kidney deficiency, soreness and weakness of waist and knees, exhaustion; more times of urination, clear urine, or incomplete emptying, or enuresis, or more times of urination at night, or urinary incontinence; men slippery sperm, premature ejaculation, women with long duration of menstruation, or leucorrhea, or easy abortion of the fetus; pale tongue, white tongue coating, weak pulse. Patients met the above two items could not be included in this study.
Kidney yang deficiency, male impotence, premature ejaculation, cold semen, women are not easy to become pregnant, loss of libido; stool frequency is not formed, defecation in the early morning; urine frequency, urine color is light, increased nocturia; cold limbs, waist and knee cold pain. Patients met the above two items could not be included in this study.
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