Objectives of Study:
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Cerebrovascular disease is the first death disease in China. The number of deaths per year is over 2 million. The mortality rate is 4-5 times that of the European and American countries. The data will further increase in the aging society, and the prevention and control task is very heavy. Of the acute stroke composition, approximately 75% fall into the category of ischemic stroke. Intravenous thrombolysis and arterial intervention are important initiatives in the treatment of ischemic stroke. Although great progress has been made in the diagnosis, treatment, and secondary prevention of cerebrovascular disease in recent years, the rehabilitation and recurrence after discharge of stroke patients cannot be optimistic.
The treatment of stroke in traditional Chinese medicine (TCM) has a long history, stroke has an acute onset, changes rapidly, and is similar to nature's wind, and therefore named stroke. Traditional Chinese medicine (TCM) considers stroke disease on the basis of the deficiency of Qi and blood within the body, and many factors, such as wind, phlegm, and stasis, work together to cause blockage of cerebral collaterals. Huangqi Guizhi Wuwu decoction, which is recorded in the synopsis of the golden chamber, consists of Radix Astragali, Radix Paeoniae lactiflora, Radix cinnamomi, Rhizoma Zingiberaceae, and Rhizoma Jujubae, and its efficacy is for regulating Yin Wei, Qufeng San Yin, Yiqi Wenjing, and xuetongbi, and it is an important prescription for treating the sequelae of stroke due to cerebral collaterals.
There are abundant clinical and basic studies on the development of Huangqi Guizhi Wuwu Decoction for the treatment of stroke. Previous studies have found that Huangqi Guizhi Wuwu decoction is effective in ameliorating limb weakness and language sludging after cerebral infarction, which can shorten the disease course and improve the motor function of the upper limbs and the ability of daily living. In addition, the combination of Huangqi Guizhi Wuwu Decoction and acupuncture in patients at the sequelae stage of cerebral infarction is highly effective in promoting the recovery of neurological function, improving the condition of blood rheology, and improving the ability of daily living.
On the basis of the clinical use of this classic formula and a previous study, combined with the physical and medication habits of native patients in Hainan, wuzhiwuwu decoction was supplemented with a combination of wufinger peach, Fangfeng, Gastrodia elata Blume, Eucommia ulmoides, Dilong, stiff silkworm, Qiang, and single Huo into Qigui FUYUAN decoction. Our previous pre experimental observation found that Qigui FUYUAN decoction during the acute phase was able to promote faster improvement of symptoms of muscle strength, language ability and limb numbness in patients with acute stroke; Return visits or visits to the rehabilitation unit for patients in the chronic phase after taking the party can also lead to faster improvements in motor and language functions of the remaining limbs and improve the quality of life. In addition, stroke patients who were actively involved in secondary prevention had a lower rate of recurrent cardio cerebrovascular events after taking Qigui FUYUAN decoction. However, Qigui FUYUAN decoction has not undergone a systematic clinical observation study, and the efficacy should be further confirmed.
Limb movement, numbness, and language function during recovery from cerebral infarction are all inextricably linked to nerve regeneration and the formation of functional neural circuits. In depth study of the effects of Qigui FUYUAN decoction on neuroregeneration will not only provide further insight into the mechanism underlying the efficacy of Qigui FUYUAN decoction, but also may provide new ideas and directions for improving the brain microenvironment and regulating neuroregeneration after stroke.
"" both diseases and changes "" and "" prevention and recurrence after illness "" are the two main contents of TCM to treat no disease. This study will observe the utility of Qigui FUYUAN decoction in post-stroke rehabilitation and recurrence prevention from the clinical point of view, deeply clarify the important role this formula plays in "" both disease prevention and recurrence "" and provide a scientific foundation for better transmission of innovative theories of traditional Chinese medicine for treating no disease and mining the clinical utility of Qigui FUYUAN decoction, Accumulating relevant scientific data for in-hospital formulation development and future new drug development will eventually benefit more stroke patients.
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