Objectives of Study:
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Taking VBM as the main analysis method, and SOD, MDA and BDNF as the main observation indexes, the effects of acupuncture and Kang method on the hippocampal volume and function of VCI patients with T2DM were discussed from the perspective of imaging, as well as the intervention mechanism of oxidative stress injury in peripheral serum, to clarify the scientific connotation of its neuroprotective mechanism for VCI patients with T2DM.
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Inclusion criteria
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1. VCI inclusion criteria for patients with T2DM :
(1) Conforming to the diagnostic points of T2DM and VCI, and having a history of ischemic or hemorrhagic stroke confirmed by cranial CT or MRI;
(2) Cognitive impairment with a Montreal Cognitive Assessment Scale (MOCA - Beijing Version) score < 26 (if the number of years of education <=12 years, 1 point will be added to the test results to adjust for cultural influence);The overall cognitive function was well preserved, and the MMSE score was >=24 points.The clinical dementia scale (CDR) score was 0.5. The clinical dementia scale (CDR) score was 0.5.No significant impairment in daily living activities, instrumental daily living ability scale (IADL) score >=16;
(3) can cooperate with the completion of nuclear magnetic functional scanning;
(4) The course of stroke ranged from 3 to 12 months;
(5) People aged 50 to 60 are right-handed;
(6) No speech and language dysfunction;
(7) Have not received acupuncture or rehabilitation treatment in the past three months;
(8) No diseases or infectious diseases such as depression and mental symptoms;
(9) No use of drugs in the following categories within 30 days prior to screening for cognitive impairment: drugs for Alzheimer's disease or dementia, anti-Parkinson's disease drugs, short-acting antianxiety agents, neurosedatives or analgesics, antiepileptics, hormones, drugs with significant cholinergic or anticholinergic side effects.
2. Inclusion criteria for T2DM group with normal cognitive function :
(1) meeting the diagnostic criteria for diabetes, and excluding stroke confirmed by cranial CT or MRI;
(2) Normal cognitive function, MOCA scale score >=26 points (if the number of years of education <=12 years, 1 point will be added to the test results to adjust for cultural influence);MMSE score >=24 points;CDR score was 0;Instrumental Daily Living Scale (IADL) score >=16 points;
(3) can cooperate with the completion of nuclear magnetic functional scanning;
(4) People aged 50 to 60 are right-handed;
(5) No speech and language dysfunction;
(6) Have not received acupuncture or rehabilitation treatment in the past three months;
(7) No diseases or infectious diseases such as depression and mental symptoms;
(8) No use of drugs in the following categories within 30 days before screening for cognitive impairment: drugs for Alzheimer's disease or dementia, anti-Parkinson's disease drugs, short-acting antianxiety agents, neurosedatives or analgesics, antiepileptics, hormones, drugs with significant cholinergic or anticholinergic side effects.
3. Inclusion criteria for healthy volunteers :
(1) They did not meet the diagnostic criteria for diabetes and were confirmed by cranial CT or MRI to exclude stroke;
(2) Normal cognitive function, MOCA scale score >=26 points (if the number of years of education <=12 years, 1 point will be added to the test results to adjust for cultural influence);MMSE score >=24 points;CDR score was 0;Instrumental Daily Living Scale (IADL) score >=16 points;
(3) can cooperate with the completion of nuclear magnetic functional scanning;
(4) 50 to 60 years old, right-handed;
(5) no brain trauma, drug and alcohol dependence may affect the brain structure and function of diseases;No depression, mental symptoms and other diseases.
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Exclusion criteria:
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1. Subjects with obvious hearing, visual and language impairments affecting cognitive function tests;
2. Acute diabetic complications such as diabetic ketoacidosis and high-level coma in the past 3 months; serious diseases such as heart, lung, liver, kidney and blood system may affect cognitive function;
3. People with central infection, brain tumor or other focal injury affecting cognition; suffering from Alzheimer's disease, Parkinson's disease and other neurological diseases that can cause dementia; history of severe brain trauma with persistent neurological deficits or known structural brain abnormalities;
4. History of alcohol, drug abuse or dependence within the past 2 years.
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