Rules of uncover or
ceasing blinding:
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The practitioners of acupuncture intervention were not blinded, but patients, efficacy evaluators and statisticians were blinded, and the blindness was revealed at the annual summary meeting of the second year of the project
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Statistical method:
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After parallel double entry of the survey data by Epi Data 3.1, the statistical software SPSS 24.0 was used for data analysis:
Both sides are used for inspection. When p value is less than or equal to 0.05, the difference is considered statistically significant.
The dosage of estazolam is expressed in (x s), and the data of the dosage of estazolam in control group and experimental group at baseline 0 weeks, 1,2,3,4 weeks after treatment and 8 weeks after follow-up are statistically analyzed and compared by single factor repeated measurement variance analysis. Comparison between groups, data in accordance with normal distribution, using two independent samples t test; The data that do not conform to normal distribution are compared by corrected t test or nonparametric test; The drug reduction rate of estazolam was expressed in (%), and X2 test was adopted. In the scales (PSQI, BWSQ, HAMA, HAMD) and EEG data, the measurement data is expressed as (x s). By using single factor repeated measurement variance analysis, the scales (PSQI, BWSQ, HAMA, HAMD) and EEG data statistical analysis of control group and experimental group at baseline 0 week, after treatment at the fourth week and during follow-up at the eighth week were compared within the group. Comparison between groups, data in accordance with normal distribution, using two independent samples t test; The data that do not conform to normal distribution are compared by corrected t test or nonparametric test; In the scales (PSQI, BWSQ, HAMA, HAMD), the case (%) of counting data is expressed by X2 test. Pearson correlation, multiple regression, coherence and phase lag index are used to construct EEG network The correlation between EEG and other observation indexes, such as dosage of estazolam, drug reduction rate of estazolam, scales (PSQI, BWSQ, HAMA, HAMD), was compared by multiple linear regression or partial correlation analysis.
In general data, the measurement data (such as age, course of disease, time of taking medicine, etc.) are expressed as (x s), and the data in accordance with normal distribution are compared by t test; The data that do not conform to normal distribution are compared by corrected t test or nonparametric test; Counting data (such as gender, family history, etc.) are expressed by use case (%), and X2 test is adopted.
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