Objectives of Study:
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1. Primary objective: To observe the effects of TCM interventions and intervention time points on the development and prognosis of CKD, to evaluate the efficacy and safety of TCM in treating CKD, and to improve the TCM diagnostic and treatment protocols for different stages of CKD. 2. Secondary objectives: (1) To explore the effects of different associated factors such as genetic factors, lifestyle, constitution, evidence, biomarkers, anxiety, depression, cognitive function, nutrition, pruritus, debility, imaging changes, etc. with CKD progression, ESRD and other adverse outcomes, and to construct a prediction model for clinical outcomes. (2) To analyze the data on treatment costs of CKD patients, conduct health economics assessment, and provide reference for subsequent comparative effectiveness studies. 3. Exploratory purpose: To analyze the etiological composition, complications, clinical features, treatment, and risk factors for deterioration of renal function in children with CKD, and to provide a basis for the comprehensive management of children with CKD.
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Exclusion criteria:
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1. Diagnosis of one of the following diseases: polycystic kidney, human immunodeficiency virus infection, cirrhosis of the liver, multiple myeloma. 2. Conditions deemed severe or unsuitable for participation in the study by the attending physician. 3. Concurrently participate in other interventional clinical trials. 4. Unable to cooperate in completing the assessment of cognitive function or have comorbidities that interfere with the assessment of cognitive function such as intracranial tumors, traumatic brain injuries, visualization, and hearing pathology. 5. CKD caused by systemic inflammatory diseases or autoimmune diseases such as lupus erythematosus. 6. Pregnant or breastfeeding women. 7. Patients with hereditary renal disease.
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