Objectives of Study:
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To compare the efficacy and safety of different lasers (ultra-picosecond laser, picosecond laser and Q-switched laser), external application of traditional Chinese medicine, laser combined with external application of traditional Chinese medicine, hydroquinone cream, and blank control in the treatment of melasma.
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Exclusion criteria:
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1. Patients with other facial pigmented diseases (such as zygomatic brown cyan nevus, white scar wind, Riehl melanosis, brown yellow disease, etc.); patients with acute facial dermatitis, advanced psoriasis, atopic dermatitis, skin cancer, autoimmune diseases, severe systemic diseases and mental illness; those who have developed herpes simplex within 6 months; those with scar constitution; those who are sensitive to light or suffering from porphyria, etc. who are not suitable for phototherapy; those who have damaged or infected skin at the treatment site; have a recent history of sun exposure.
2. Pregnant or lactating patients.
3. Systemic application of tranexamic acid, glucocorticoids, contraceptives or retinoids within 6 months before treatment; oral photosensitive drugs within 4 weeks before treatment; topical treatment of melasma drugs (such as hydroquinone, tretinoin, arbutin, azelaic acid, tranexamic acid, glucocorticoids, etc.) within 4 weeks before treatment; history of facial injections and fillers, metal wire implantation, laser, intense pulsed light, and radiofrequency treatments within 6 months.
4. Chloasma is in the active stage: recently, the area of the skin lesions has expanded, the color has deepened, the skin lesions have become reddish, and the skin lesions have become red after scratching.
5. It is impossible to avoid sunlight or sun protection after surgery (such as: perennial outdoor workers, daily life environments are exposed to high ultraviolet rays).
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