Objectives of Study:
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1.To explore the optimal dose of compound Solidago solani spray in the treatment of pharyngeal pain caused by children with acute pharyngitis (wind-heat syndrome) and evaluate its immediate analgesic effect; Observation indicators: onset efficiency of immediate analgesia, onset time/duration of immediate analgesia, disappearance time/rate of pharyngeal pain, efficacy of pharyngeal signs, VAS score of pharyngeal pain, disease recovery rate, efficacy of TCM syndromes. 2.To observe the clinical safety of compound Solidago officinalis spray. Incidence of clinical adverse events/adverse reactions, vital signs, laboratory tests, etc. 3Overall design of test The method of block randomization, double blind, dose exploration, multi-center, two stage adaptive design was adopted. It includes dose exploration stage (stage 1) and dose confirmation stage (stage 2).
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Exclusion criteria:
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1. Children or their parents/caregivers have difficulty in understanding or cooperating with the use of VAS. 2. At the time of initial diagnosis, the condition of the child is serious, such as lack of energy, restlessness, headache, or pain in body muscles, and antipyretic and analgesic drugs are needed. 3. Suppurative tonsillitis, abscess around tonsil or posterior pharyngeal wall, or white blood cell count, absolute value of neutrophil and CRP > ULN, which were considered to be caused by bacterial infection. 4.Children with measles, scarlet fever and other infectious diseases. 5.Children with acute laryngitis, otitis media, bronchitis, pneumonia and other complications. 6. Children with serious primary diseases of heart, lung, liver, kidney, metabolism, hematopoietic, immune, nervous, mental and other systems. 7. Allergic to the test drug (compound Solidago solidago spray) and its components, and allergic to antipyretic analgesics. 8.Patients who had taken acetaminophen, ibuprofen and other antipyretic and analgesic drugs within 6 hours before enrollment. 9.According to the judgment of the researcher, it is not suitable to be included in the group
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